Flow microreactor synthesis in organo-fluorine chemistry

• Hideki Amii,
• Aiichiro Nagaki and
• Jun-ichi Yoshida

Beilstein J. Org. Chem. 2013, 9, 2793–2802, doi:10.3762/bjoc.9.314

• 615-8510, Japan 10.3762/bjoc.9.314 Abstract Organo-fluorine compounds are the substances of considerable interest in various industrial fields due to their unique physical and chemical properties. Despite increased demand in wide fields of science, synthesis of fluoro-organic compounds is still often

• -fluorine compounds. For the future, continuous flow microreactor chemistry will make a breakthrough in developing new chemical production with highly efficiency and unexploited fluorinated intermediates by the ingenious strategy, and will afford fluorine-containing useful materials. Direct fluorination

• gaining a significant importance in wide field of science and technology, and there have been the associated growing need for new and more efficient synthetic methods. As highlighted here, each of these elegant flow microreactor syntheses surely supplies the innovative methods for the synthesis of organo

Cu-catalyzed trifluoromethylation of aryl iodides with trifluoromethylzinc reagent prepared in situ from trifluoromethyl iodide

• Yuzo Nakamura,
• Motohiro Fujiu,
• Tatsuya Murase,
• Yoshimitsu Itoh,
• Hiroki Serizawa,
• Kohsuke Aikawa and
• Koichi Mikami

Beilstein J. Org. Chem. 2013, 9, 2404–2409, doi:10.3762/bjoc.9.277

• . Keywords: organo-fluorine; Ruppert–Prakash reagent; trifluoromethyl; trifluoromethylation; trifluoromethyl zinc; Introduction Organo-fluorine compounds have received considerable attention in the fields of biomedical chemistry, agrochemistry, and organic material science due to their unique chemical

Synthesis of enones, pyrazolines and pyrrolines with gem-difluoroalkyl side chains

• Assaad Nasr El Dine,
• Ali Khalaf,
• Danielle Grée,
• Olivier Tasseau,
• Fares Fares,
• Nada Jaber,
• Philippe Lesot,
• Ali Hachem and
• René Grée

Beilstein J. Org. Chem. 2013, 9, 1943–1948, doi:10.3762/bjoc.9.230

• successfully developed for these sequential reactions. By carrying out various types of Pd-catalyzed coupling reactions for compounds with a p-bromophenyl substituent a route to focused chemical libraries was demonstrated. Keywords: 19F/1H HOESY; gem-difluoroalkyl derivatives; organo-fluorine compounds

Organo-fluorine chemistry II

• David O'Hagan

Beilstein J. Org. Chem. 2010, 6, No. 36, doi:10.3762/bjoc.6.36

• industry servicing these industrial sectors. New innovations and insights into the synthesis and the nature and behaviour of organo-fluorine compounds continue to intrigue and this Thematic Series offers a glimpse into the level of activity in the area. I am delighted that all of the authors have agreed to

• firmly as a special interest area of the journal. The first series in 2008 presented contributions representing a wide range of organic fluorine chemistry [1][2][3][4][5][6][7][8][9][10] and this series continues that trend exploring the synthesis and properties of a new range of organo-fluorine

• compounds. Contributions have been received from research groups in Australia, China, Germany, Japan, North America, Ukraine and the United Kingdom, representing a particularly international research community. The introduction of fluorine remains an important specialism in organic chemistry for modulating

Themed series in organo- fluorine chemistry

• David O'Hagan

Beilstein J. Org. Chem. 2008, 4, No. 11, doi:10.3762/bjoc.4.11

• ]. Organo-fluorine compounds have also found a significant role in soft materials chemistry such as liquid crystals, photoresist polymers and self assembling monolayers [3]. Allied to this breadth of activity is a steady development in the number and range of fluorination reagents and methodologies. DAST